Study on Antioxidant Activity and Development of Skin Care Serum Products from Papaya Extracts
Article Sidebar
Main Article Content
Abstract
The aim of this research was to study the DPPH antioxidant activity of crude extracts from ripe papaya seeds (fresh seed and dried seed) by using 3 types of solvents as water (W) glycerin (G) and monopropylene glycol (MP) at 3 different solvent ratios as 1:10, 1:15, 1:20 (w/v) by ultrasonic technique (30 minutes). The crude extracts were tested for DPPH antioxidant activity and analyzed the total phenolic content. Then a basic serum (PS1) and a serum with containing the best antioxidant activity of papaya seed crude extract 2 different formulations (PS2 and PS3) were prepared and tested the stability of the serum, and pH value. The 3 serum formulations were tested for absorption into the mask granule at 0, 1, 5, 10, 15 and 20 minutes. The results showed that the crude extract from fresh papaya seeds extracted with glycerin 1:10 (w/v) (FS-G-10) had the best antioxidant activity DPPH (EC50 0.685 g/mL) and the highest total phenolic content (121.94 ±0.189 mg GAE/100 g FW). The study, results of the serum stability showed that the PS2 serum had the best stability, and all 3 serums had a pH 6 value. Effect of how long to take time for the mask granule to absorb the serum (PS1, PS2 and PS3) was found that the maximum time for the mask granule to absorb the serum was 20 minutes. According to the results of this research, fresh papaya seed extract can be used as an ingredient in nourish skin serum or applied to the serum with compressed facial mask sheet to further enhance the effectiveness of skin care.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
K. Zhou, H. Wang, W. Mei, X. Li, Y. Luo and H. Dai, “Antioxidant Activity of Papaya Seed Extracts,” Molecules, vol. 16, no. 8, pp. 6179-6192, Jul. 2011. doi:10.3390/molecules1608617.
I. Kyei-Barffour, R.K.B. Kwarkoh, D.O. Acheampong, A.S. Brah, S.A. Akwetey and B. Aboagye, “Alkaloidal extract from Carica papaya seeds ameliorates CCl4-induced hepatocellular carcinoma in rats,” Heliyon, vol. 7, no. 8, pp. 1-10, Aug. 2021. DOI: 10.1016/j.heliyon.2021.e07849.
C.R. Malacrida, M.K. and N. Jorge, “Characterization of a high oleic oil extracted from papaya (Carica papaya L.) seeds,” Food Science and Technology (Campinas), vol. 31, no. 4, pp. 929-934, Dec. 2011.
S. Lar-Abia, J. Welti-Chanes and M.P. Cano, “Effect of ultrasound-assisted extraction of carotenoids from papaya (Carica papaya L. cv. Sweet Mary) using vegetable oils,” Molecules, vol. 27, no. 3, pp. 1-18, Jan. 2022. https://doi.org/10.3390/ molecules2703 0638.
R. Saini, A. Mittal and V. Rathi, “Formulation & in-vitro antioxidant analysis of anti-ageing cream of Carica papaya fruit extract,” Indian Journal of Drugs, vol. 4, no. 1, pp. 8-14, Mar., 2016.
M.S. Adhikar, V.A. Chavan and N.B. Gaikwad, “Formulation and evaluation of face serum containing Carica papaya and Aloe vera,” International Journal of Creative Research Thoughts, vol. 12, no, 6, pp. 121-132, Jun. 2024.
G. Dudhat, A. Patwekari, M. Jadhav and S. Kashid, “Unlocking the cosmetic potential of Carica papaya, it’s phytochemical and pharmacological review,” International Journal of Creative Research Thoughts, vol. 12, no. 12, pp. 89-100, Dec. 2024.
E. Panzarini, M. Dwikat, S. Mariano, C. Vergallo and L. Dini, “Administration dependent antioxidant effect of Carica papaya seeds water extract,” Evidence-Based Complementary and Alternative Medicine, vol. 1, pp. 1-13, Mar. 2014.
R. Ahdyani, R. Patimah, E. Fatmasari, S. Rahayu and R. Annisa, “Influence of hydroxyethyl cellulose and glycerin concentration variations on the physicochemical stability of niacinamide-loaded nanoparticle serum formulations,” Ad-Dawaa Journal of Pharmaceutical Sciences, vol. 8, no. 2, pp. 221-234, Dec. 2025.
S. Mankar and S. Vaidya, “Review on face serum,” Asian Journal of Pharmaceutics, vol. 18, no. 3, pp. 740-749, Aug. 2024.
A.P. Mangle, R.L. Bakal, P.R. Hatwar, V.S. Kalamb and K.S. Jumde, “The role of serums in addressing skin concerns: Exploring efficacy, safety and Trends in Beauty and Skincare,” GSC Biological and Pharmaceutical Science, vol. 29 no. 2, pp. 066-076. Sep. 2024.
A.B.L. Ongom, P. Pranamornkith and T. Pranamornkith, “Intermittent warming affects postharvest quality and chilling injury of ‘Holland’ papaya fruit,” Journal Thai Interdisciplinary Research, vol. 14, no. 2, pp. 20-27, May. 2019.
S. Chaijan, M. Chaijan, U. Uawisetwathana, A. Panya, N. Phonsatta, K. Shetty and W. Panpipat, “Phenolic and metabolic profiles, antioxidant activities, glycemic control, and anti-inflammatory activity of three Thai papaya cultivar leaves,” Foods, vol. 13, no. 11, pp. 1-19, May. 2024.
S. Lara-Abia, G. Lobo-Rodrigo. J. Welti-Chanes and M.P. Cano, “Carotenoid and carotenoid ester profile and their deposition in plastids in fruits of new papaya (Carica papaya L.) varieties from the Carnary Islands,” Foods, vol. 10, no. 2, pp. 1-26. Feb. 2021.
Y.D. Nakhate, K.S. Talekar, S.V. Giri, R.D. Vasekar, H.C. Mankar and P.R. Tiwari, “Pharmacological and chemical composition of Carica papaya: on overview,” World Journal of Pharmaceutical Research, vol. 8, no. 5, pp. 811-821, Mar. 2019.
R.I. Adeoye, E.T. Olopade, I.O. Olayemi, K. Okaiyeto and M.O. Akiibinu, “Nutritional and therapeutic potentials of Carica papaya Linn. Seed: a comprehensive review,” Plant Science Today, vol. 11, no. 2, pp. 671-680, May. 2024.
Z.R. Addai, A. Abdullah, S.A. Mutalib, K.H. Musa and E.M.A. Douqan, “Antioxidant activity and physicochemical properties of mature papaya fruit (Carica papaya L. cv. Eksotida),” Advance Journal of Food Science and Technology, vol. 5, no. 7, pp. 859-865, Jul. 2013.
A.S. Baesso, D.J. da Silva, A.K. Soares, M.M. da Silva Paula, P.H.G. de Canemartori, “Biosynthesis of gold nanoparticles using papaya seed extract for the functionalization of nanocellulose membranes,” Industrial Crops & Products, vol. 197, Mar. 2023.
O.A. Iordănescu, M. Băla, D.G. Pane, S.E. Zippenfening, M.I. Cugerean, M.I. Petroman, D.I. Hădărugă, N.G. Hădărugă and M. Rivi, “A DPPH Kinetic approach on the antioxidant activity of various parts and pipening levels of papaya (Carica papaya L.) Ethanolic extracts,” Plants, vol. 10, no. 8, pp.1-14, Aug. 2021.
S.R. Omar, F. Aminuddin, L. Karim, N. Suhaimi, and S.N. Omar. “Acceptability of novel antioxidant ice cream fortified with nutritious Carica papaya seed,” Journal of Academia, vol. 8 no. 1, pp. 7-17, Mar. 2020.
S.M. Robles-Apodaca, R.I. González-Vega, S. Ruíz-Cruz, M.I. Estrada-Alvarado, L.A. Cira-Chávez, E. Márquez-Ríos, C.L. Del-Toro-Sánchez, J. de Jesús Ornelas-Paz, G.M. Suárez- Jiménez and V.M. Ocaño-Higuera. “Optimization of extraction process for improving polyphenols and antioxidant activity from papaya seeds (Carica papaya L.) using response surface methodology,” Processes. vol. 12, no. 12, pp. 1-24, Dec. 2024.
