In vivo analgesic, antipyretic and anti-inflammatory potential of ethanol extract from Plukenetia volubilis Linneo leaves in mice
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Abstract
Plukenetia volubilis L. is traditionally utilized for managing joint pain, muscle discomfort, wound healing, and infection prevention. Despite this extensive use, the specific analgesic, anti-inflammatory, and antipyretic activities of the ethanol extract from P. volubilis leaves (PVEE) remain underexplored, warranting further investigation. The study results revealed that PVEE possesses notable analgesic effects, as evidenced by a significant increase in tail-flick latency (p < 0.05), inhibition of pain responses (p < 0.05), a reduction in writhing frequency (p < 0.05), and a decrease in paw swelling (p < 0.05) in inflammatory models. Additionally, PVEE demonstrated antipyretic properties by significantly reducing rectal temperature (p < 0.05) in a yeast-induced fever model. Furthermore, the extract exhibited strong anti-inflammatory effects, as it significantly reduced paw edema (p < 0.05) and inhibited the release of pro-inflammatory cytokines, such as IL-6, IL-1β, and TNF-α (p < 0.05). These results highlight the potential of PVEE as a promising therapeutic option for pain relief, fever reduction, and inflammation management.
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