Bioactive properties and therapeutic potential of Padina australis Hauck (Dictyotaceae, Ochrophyta)
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Abstract
Seaweeds are known sources of biologically active substances with diverse bioactive properties important in the synthesis of medically important novel drugs. The bioactive properties of brown macroalga, Padina australis Hauck were studied. Results showed that the seaweed contain a total phenolic content of 13.85 ± 0.04 mg GAE/g. Antioxidant efficiency of P. australis are characterized by having potent ABTS+ scavenging activity and high copper reduction capacity with IC50 value of 138 μg/ml and 24.47 μg/ml respectively. Evaluation of tyrosinase and elastase inhibition properties showed that P. australis extract has potent inhibitory activity with IC50 of 32 μg/ml and IC50 of 93 μg/ml, respectively more effective than kojic acid and tocopherol. In addition, in vitro assessment of alpha-glucosidase and alpha-amylase inhibition property of the alga showed that P. australis extract have effective inhibitory activity with IC50 values of 5.90 μg/ml and 41 μg/ml, respectively, more potent as compared to acarbose (standard anti-diabetic drug). The seaweed extract exhibited potent antibacterial activities against medically important bacterial pathogens such as Klebsiella pneumoniae (Minimum Inhibitory Concentration (MIC) = 125 μg/ml), Methicillin-resistant Staphylococcus aureus (MIC = 250 μg/ml), Pseudomonas aeruginosa (MIC = 125 μg/ml), and Staphylococcus aureus (MIC = 250 μg/ml). The current investigation is a pioneering study in the Philippines that shows the potential of P. australis as source of bioactive compounds with important pharmacological applications.
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