Identification of lovastatin analogs-producing Pleurotus cultivars in southern Vietnam
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Abstract
Pleurotus mushrooms have been widely cultivated worldwide due to their nutritional and medicinal value. Numerous bioactive compounds such as polysaccharides, polyphenols, proteins, and amino acids, have been well documented in its fruiting bodies. However, lovastatin known as an anti-lipidemic medicinal compound produced by several Pleurotus strains is neglected. This study aimed to identify local Pleurotus strains capable of producing lovastatin analogs collected from southern Vietnam. Accordingly, 31 Pleurotus strains were isolated and belonged to 5 morphotypes: blue oyster, golden oyster, abalone, oyster, and phoenix. Lovastatin analogs were detected using a state-of-the-art method quantitative 1H nuclear magnetic resonance (qHNMR). As a result, among 31 strains of Pleurotus mushrooms, 4 strains were capable of synthesizing lovastatin analogs. In which, one strain belonged to oyster morphotypes (Pleurotus ostreatus s. l.) and 3 strains were phoenix morphotypes (Pleurotus pulmonarius s. l.). This is the first to identify the production of lovastatin analogs by phoenix mushrooms.
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