Antidiabetic agents with -glucosidase inhibition and antioxidant capacity from the shoots of Clausena cambodiana Guill

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Published: Jul 20, 2017
Keywords:
Clausena cambodiana Gill Clausenidin -Glucosidase inhibitor Antioxidant

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Damsud, T.
Program of Applied Biology, Faculty of Science and Technology, Rajamangala University of Technology Srivijaya, Thung Song, Nakhon Si Thammarat 80110, Thailand
Chanwun, T.
Program of Palm Oil and Oleochemical Technology, Faculty of Science and Technology, Rajamangala University of Technology Srivijaya, Thung Song, Nakhon Si Thammarat 80110, Thailand
Kaewpiboon, C.
Departments of Biology, Faculty of Science, Thaksin University, Phatthalung 93210, Thailand.

Abstract

Separation of CH2Cl2 crude extract of the shoots of Clausena cambodiana Guill led to the isolation of four known compounds including quercetin (1), sinensetin (2), clausenidin (3) and b-sitosterol (4). Quercitin exhibited highest antioxidant capacity with IC50 value 8.45±1.42 mM, which are comparable to ascorbic acid. Clausenidin exhibited strong inhibitory activity specifically against sucrase with an IC50 value 12.32±3.60 mM, which are more potent inhibition than acarbose (IC50 = 32.58±3.92 mM) using as the positive control. In addition, the kinetic mechanism of 3indicated that it retarded sucrase in a noncompetitive manner.

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How to Cite
Damsud, T., Chanwun, T., & Kaewpiboon, C. (2017). Antidiabetic agents with -glucosidase inhibition and antioxidant capacity from the shoots of Clausena cambodiana Guill. International Journal of Agricultural Technology, 13(4), 449–456. retrieved from https://li04.tci-thaijo.org/index.php/IJAT/article/view/6753
Issue
Vol. 13 No. 4 (2017): July
Section
Original Study
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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